Pyrrole Disorder update

Pyrrole disorder can be described as a complex disorder. The causes of pyrrole disorder are not completely understood. There has been an influx of people with potential pyrrole disorder in clinic in the last year or so, especially since the website post last year.

All humans excrete small quantities of hydroxyhemopyrrolin-2’one (HPL) in urine. The level of HPL is tested via a urine test. The level of HPL increases with physical or emotional stress. Elevated HPL has been observed in people with depression. Some laboratories have set the normal concentration of HPL in urine as less than 25 μg/dL. However, practitioners may associate HPL levels twice that amount as being elevated.

The signs and symptoms of pyrrole disorder are similar to that of vitamin B6 and zinc deficiency. The HPL molecule can bind up zinc and vitamin B6 and excrete them, leading to a deficiency.

Hopefully research will provide more information about Pyrrole Disorder the next few years. One of my aims is to conduct clinical trials investigating the levels of HPL and mental health, especially in depression and anxiety, and cardiometabolic disease.